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C7E3 FAB
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DeCS
Descriptor
English
:
Abciximab
Descriptor
Spanish
:
Abciximab
Descriptor
Portuguese
:
Abciximab
Synonyms
English
:
CentoRx
Chimeric 7E3 Fab
Clotinab
Fab, Chimeric 7E3
ReoPro
c7E3 Fab
Tree Number:
D12.644.541.500.650.125
D12.776.124.486.485.114.224.060.125
D12.776.124.486.485.680.650.125
D12.776.124.790.651.114.224.060.125
D12.776.124.790.651.680.650.125
D12.776.377.715.548.114.224.200.125
D12.776.377.715.548.680.650.125
Definition
English
:
A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks
PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX
, potently inhibiting
PLATELET AGGREGATION
. It is used in treatment of refractory unstable angina, and for prevention of ischemic complications in
patients
undergoing percutaneous coronary procedures such as
ANGIOPLASTY
;
ATHERECTOMY
; or stenting.
Pharmacological Action:
Anticoagulants
Platelet Aggregation Inhibitors
History Note
English
:
2019 (1994)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
57585
Unique Identifier:
D000077284
Occurrence in VHL
:
Similar:
DeCS